Fenbendazole, marketed under the brand name Pancur and Safe-Guard, is a medication used to treat parasites and certain worms in animals (roundworms, hookworms, whipworms, and some tapeworms). But it’s also the main ingredient in a cancer-fighting regimen being touted on TikTok and Facebook—known as the Joe Tippens protocol. Despite the popularity of the protocol, there’s no evidence fenbendazole cures cancer in humans.
Researchers are currently examining the potential of fenbendazole for other uses, including as a treatment for cancer, and some preclinical studies suggest it can suppress cancer cell growth. It may work by blocking the growth of microtubules in cancer cells, which provide structure to all body cells. Other drugs that target this process—including conventional chemotherapy—have shown promise in treating certain types of cancer.
But this research is still early, and it would take large-scale clinical trials in people to determine whether fenbendazole is an effective treatment for cancer. In fact, most patients we spoke to said they got the fenbendazole-cancer information through acquaintances or friends, rather than TV or YouTube.
We investigated the effect of fenbendazole on the expression of autophagy proteins in colorectal cancer cells. The results showed that fenbendazole increased the expression of Beclin-1 and LC3-I, but did not affect caspase-8-dependent apoptosis. Moreover, fenbendazole enhanced necroptosis by decreasing the expression of GPX4. We concluded that fenbendazole triggers apoptosis and necroptosis in CRC cells through both beclin-1-dependent and GPX4-dependent mechanisms.fenbendazole for cancer
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