Fenben lab fenbendazol is an antiparasitic drug (anthelmintic) in the benzimidazole family that has been widely used as a dewormer in dogs and cats for nearly 60 years. This broad-spectrum class of drugs (called the benzimidazoles) also includes albendazole, metronidazole, and tinidazole and is highly effective against most roundworm species.
The anthelmintic activity of fenbendazole is attributed to its inhibition of parasite cell division by blocking the synthesis of dNAP, an important step in mitosis. It is also believed to affect the dNAP transport system and inhibit the formation of microtubules, which are structural components of cells that give them shape and support (1-3). The drug is thought to act via its binding to tubulin, which is a major component of the cytoskeleton. Fenbendazole blocks the polymerization of tubulin, causing microtubules to break down, thus disrupting cellular organization and function. It has been reported that fenbendazole also exhibits anticancer effects in animals, possibly due to its antitubulin effects and its interference with the cellular microtubule-stabilizing agents, vinca alkaloids, and taxanes (4-9).
Mice were fed a diet of control, vitamin B12-supplemented, or fenbendazole-supplemented mPEG-b-PCL micelles for 2 wk prior to subcutaneous flank implantation with 3 x 107 lymphoma cells. Tumor growth was measured by caliper at 4-d intervals until the largest tumor reached a volume of 1500 mm3. The vitamin and fenbendazole groups showed no significant differences in tumor growth compared with controls, but mice treated with fenbendazole plus vitamins showed significantly slower tumor progression than either of the other treatment groups.
No comments:
Post a Comment